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KMID : 0369820050350060411
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Jorunal of Korean Pharmaceutical Sciences
2005 Volume.35 No. 6 p.411 ~ p.416
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Study on the In Vitro Sun Protection Factor Effect of Nanosuspensions Prepared Using Bead Mill and High Pressure Homogenizer
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박상현/Park SH
안정호/문권기/배덕환/김민수/이시범/이태완/우종수/황성주/Ahn JH/Moon KK/Bae DH/Kim MS/Lee SB/Lee TW/Woo JS/Hwang SJ
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Abstract
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The aim of the present work was to prepare the nanosuspension of inorganic pigment which shows light reflection and scattering as efficient sunscreen. The zinc oxide (ZnO) was chosen as an inorganic pigment, and high pressure homogenizer and bead mill have been used for the preparation of nanosuspension. The ZnO nanosuspensions were characterized by particle size, in vitro sun protection factor (SPF) and UV transmittance. ZnO nanosuspension prepared by bead mill showed the average diameter of 119±4nm, resulting in the high value of SPF (28.74±2.06,n=20), while that prepared by high pressure homogenizer showed the average diameter of 751±32nm with the relative lower value of SPF (21.38±1.94n=20). In addition, the film of ZnO nanosuspension prepared by bead mill was showed a high visible ray (VIS) transmittance, indicating a high transparency. In conclusion, a physically stable ZnO nanosuspension in cyclomethicone was successfully prepared using bead mill for the suitable sunscreen preparations.
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KEYWORD
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Nanosuspension, Zinc oxide, Bead mill, High pressure homogenizer, Sunscreen, Sun protection factor, SPF
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